While I have gone for this with hockey, hunting down base cards for players who were either the only, or one of the few players to be born in a certain country or state. With the latest COMC package, I did the same and added some football, basketball and baseball to that mini-collection. So, cross referencing with the birthplaces portion of pro-football-reference, here's a quick world tour! Cards appear chronologically and unless otherwise stated, said person is the only person born in that particular country to reach the NFL.
OF these guys, Joseph, Jenkins and Cherilus are all still active.